Cranium Kabookii only uses one Wii Remote. In some cases, after you've finished playing a title that uses 2 or more Wii remotes, Cranium Kabookii will try to use both Wii Remotes by mapping functionality of one Wii Remote on both Wii Remotes.
To avoid this from happening, before playing Cranium Kabookii, reset the Wii Console or turn it off then back on. This operation can be done before or after inserting the Cranium Kabookii disc into the Wii Console. If that doesn’t help, try removing the batteries from the second Wiimote before they restart the game.